Marta MADAGHIELE

Marta MADAGHIELE

Assegnista di ricerca

marta.madaghiele@unisalento.it

Dipartimento di Ingegneria dell'Innovazione

Edificio La Stecca - S.P. 6, Lecce - Monteroni - LECCE (LE)

Ufficio 1° Piano - Edificio La Stecca, Piano 1°

Telefono +39 0832 29 7236

Area di competenza:

SSD ING-IND/22

Scienza e Tecnologia dei Materiali

Scienza e Tecnologia dei Materiali Polimerici

Biomateriali

Orario di ricevimento

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Curriculum Vitae

Marta Madaghiele graduated in Materials Engineering, summa cum laude, at the University of Lecce, Italy (2003). During her Ph.D. Program in Materials Engineering at the same University (2004-2008), she focused her research activities on the development of polymer-based porous scaffolds for tissue engineering, as well as on the synthesis of biocompatible hydrogels for several biomedical applications. She performed part of her Doctoral Research Program at the VA Tissue Engineering Laboratories of the VA Boston HealthCare System, in Boston, MA, USA, working on the design of collagen-based scaffolds for spinal cord regeneration in an animal model, and collaborating with the Fibers and Polymers Lab at the Department of Mechanical Engineering of the Massachusetts Institute of Technology, Cambridge, MA, USA. After a post-doc fellowship, she is currently a researcher (non-tenure-track position) at the Department of Engineering for Innovation of the University of Salento (formerly University of Lecce). Her main research interests deal with the synthesis and characterization of polymeric devices for biomedical applications, including: collagen-based scaffolds for regenerative medicine, with a special focus on the peripheral and central nervous systems; polymeric micro- and nano-spheres for the controlled delivery of biomolecules; hydrogels for cell encapsulation; hydrogels as soft tissue fillers and scaffolds.

 


Corso di Laurea Magistrale in Materials Engineering and Nanotechnology

Biomaterials (9 CFU)

II semestre (01/03/2017-01/06/2017)

Teachers: Prof. Alessandro Sannino (5 CFU); Ing. Marta Madaghiele (2 CFU); Ing. Francesca Scalera (2 CFU)

Objectives: The aim of the course is to provide students with basic knowledge on the design of medical devices for given applications, from biomaterial choice to manufacturing technologies. Particular attention is given to the development of the following devices: a) artificial prostheses; b) scaffolds for regenerative medicine and tissue engineering; c) devices for controlled drug release.

Learning outcomes: This course aims to highlight the properties of biomaterials affecting their performance as medical implants, scaffolds for tissue engineering and drug delivery devices. At the end of the course, students are expected to:

  • understand the physiological response to medical implants;
  • know the principles of scaffold design and related manufacturing technologies;
  • know the principles of drug delivery design;
  • identify the most suitable biomaterial(s) for given applications;
  • know the methods for bulk and surface characterization of biomaterials.

Programme

  • Introduction on biomaterials. Metals, bioceramics, natural and synthetic polymers (6 hours).
  • Viscoelasticity of polymers and biological tissues. Hydrogels: definition and applications; thermodynamics and kinetics of swelling; crosslink density (rubber elasticity theory) (16 hours). Laboratory activities (4 hours).
  • Diffusion in polymers and principles of drug delivery devices.Diffusion and erosion-based mechanisms. Examples: hydrogels, micro- and nano-particles. Transdermal drug release devices. Drug targeting for cancer therapy (12 hours). Laboratory activities (2 hours).
  • Physiological response to permanent implants. Definitions and examples of favourable or adverse responses. Wound healing: acute and chronic response. Examples of permanent implants: orthopedic prostheses; contact lenses; stents (8 hours).
  • Principles of tissue engineering. Scaffold design: structure and properties; porosity, degradation, mechanical properties, manufacturing technologies. Bioreactors; cells for tissue engineering (16 hours). Laboratory activities (5 hours).
  • Case studies: biomaterials and scaffolds for regeneration of nerves, bone, cartilage, tendons and ligaments. Biomaterials for cell encapsulation (9 hours).
  • Classification and regulatory issues for medical devices (3 hours).
  • Light variations of the time schedule will be possible according to the class interest in the main topics.

Requirements: Basic knowledge on polymer science and technology is suggested.

Final exam: oral. Final exam will consists of an oral interview, during which the student is expected to show complete knowledge and comprehension of the topics of the course.

Reception: Upon appointment by email

Suggested readings

[1] Pietrabissa, R. Biomateriali per protesi e organi artificiali. Patron Editore.

[2] Yannas I.V. Tissue and Organ Regeneration in Adults. Springer

[3] Class notes and slides

Didattica

A.A. 2017/2018

BIOMATERIALS (ING-IND/22)

Corso di laurea MATERIALS ENGINEERING AND NANOTECHNOLOGY

Lingua INGLESE

Crediti 9.0

Anno accademico di erogazione 2017/2018

Per immatricolati nel 2016/2017

Struttura DIPARTIMENTO DI INGEGNERIA DELL'INNOVAZIONE

Percorso MATERIALS FOR BIOMEDICAL APPLICATIONS

A.A. 2016/2017

BIOMATERIALS (ING-IND/22)

Corso di laurea MATERIALS ENGINEERING AND NANOTECHNOLOGY

Crediti 9.0

Anno accademico di erogazione 2016/2017

Per immatricolati nel 2015/2016

Struttura DIPARTIMENTO DI INGEGNERIA DELL'INNOVAZIONE

Percorso MATERIALS FOR BIOMEDICAL APPLICATIONS

A.A. 2015/2016

BIOMATERIALS (ING-IND/22)

Corso di laurea MATERIALS ENGINEERING AND NANOTECHNOLOGY

Crediti 9.0

Anno accademico di erogazione 2015/2016

Per immatricolati nel 2014/2015

Struttura DIPARTIMENTO DI INGEGNERIA DELL'INNOVAZIONE

Percorso MATERIALS FOR BIOMEDICAL APPLICATIONS

A.A. 2014/2015

CELL TISSUES INTERACTION (ING-IND/34)

Corso di laurea MATERIALS ENGINEERING AND NANOTECHNOLOGY

Crediti 6.0

Anno accademico di erogazione 2014/2015

Per immatricolati nel 2013/2014

Struttura DIPARTIMENTO DI INGEGNERIA DELL'INNOVAZIONE

Percorso MATERIALS FOR BIOMEDICAL APPLICATIONS

Torna all'elenco
BIOMATERIALS (ING-IND/22)

Corso di laurea MATERIALS ENGINEERING AND NANOTECHNOLOGY

Settore Scientifico Disciplinare ING-IND/22

Anno accademico 2016/2017

Anno accademico di erogazione 2017/2018

Anno 2

Semestre Secondo Semestre (dal 01/03/2018 al 01/06/2018)

Lingua INGLESE

Percorso MATERIALS FOR BIOMEDICAL APPLICATIONS (A52)

BIOMATERIALS (ING-IND/22)
BIOMATERIALS (ING-IND/22)

Corso di laurea MATERIALS ENGINEERING AND NANOTECHNOLOGY

Settore Scientifico Disciplinare ING-IND/22

Anno accademico 2015/2016

Anno accademico di erogazione 2016/2017

Anno 2

Semestre Secondo Semestre (dal 01/03/2017 al 02/06/2017)

Lingua INGLESE

Percorso MATERIALS FOR BIOMEDICAL APPLICATIONS (A52)

BIOMATERIALS (ING-IND/22)
BIOMATERIALS (ING-IND/22)

Corso di laurea MATERIALS ENGINEERING AND NANOTECHNOLOGY

Settore Scientifico Disciplinare ING-IND/22

Anno accademico 2014/2015

Anno accademico di erogazione 2015/2016

Anno 2

Semestre Secondo Semestre (dal 29/02/2016 al 03/06/2016)

Lingua INGLESE

Percorso MATERIALS FOR BIOMEDICAL APPLICATIONS (A52)

BIOMATERIALS (ING-IND/22)
CELL TISSUES INTERACTION (ING-IND/34)

Corso di laurea MATERIALS ENGINEERING AND NANOTECHNOLOGY

Settore Scientifico Disciplinare ING-IND/34

Anno accademico 2013/2014

Anno accademico di erogazione 2014/2015

Anno 2

Semestre Secondo Semestre (dal 02/03/2015 al 06/06/2015)

Lingua INGLESE

Percorso MATERIALS FOR BIOMEDICAL APPLICATIONS (A52)

CELL TISSUES INTERACTION (ING-IND/34)

Pubblicazioni

An updated list of publications can be found in the below pdf file.

Scarica pubblicazioni

Temi di ricerca

Main research topics include:

  • collagen-based scaffolds for regenerative medicine, with a special focus on the peripheral and central nervous systems;
  • polymeric micro- and nano-spheres for the controlled delivery of biomolecules;
  • hydrogels for cell encapsulation;
  • hydrogels as soft tissue fillers and scaffolds.