Luigino TROISI

Luigino TROISI

Professore I Fascia (Ordinario/Straordinario)

Settore Scientifico Disciplinare CHIM/06: CHIMICA ORGANICA.

Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali

Centro Ecotekne Pal. B - S.P. 6, Lecce - Monteroni - LECCE (LE)

Ufficio, Piano terra

Telefono +39 0832 29 8701 +39 0832 29 8871

Ordinario di Chimica Organica, settore disciplinare CHIM06
Area di competenza:

Chimica Organica

Chimica Organica applicata

Metodi fisici in chimica Organica

Laboratorio di Chimica

Chimica Organica dell'Ambiente

Biorganica

Chimica delle Sostanze Coloranti

Sintesi di nuovi prodotti ad uso farmaceutico e materiali

Tecniche analitiche per prodotti organici (IPA; DIOSSINE; Pesticidi ecc.): Spettrometria di Massa, Risonanza Magnetica Nucleare, Infrarosso,  HPLC e Gas Cromatografia, MaldiTOF .

Orario di ricevimento

dal Lunedi al Venerdi  dalle 9:00 alle 19:00  fuori dagli orari di Lezione

è consigliabile chiedere appuntamento per evitare attesa.

Recapiti aggiuntivi
Racale, via Dalla Chiesa, 16 tel. 0833 585397 cell. 392.9599948
Visualizza QR Code Scarica la Visit Card

Curriculum Vitae

 Nato a Racale (LE) il 6.8.46, ha conseguito:

la Maturità Classica nel 1965

la Laurea in Chimica nel 1970

una borsa di Studio dal 1.11.1971 al 30.3.1974

Contrattista dal 1.30.1974 al 15.01.1977

Professore incaricato per il corso di "Laboratorio di Chimica Organica ed Analisi Organica"  per gli anni 1977-1992   Università di Bari

Assistente Supplente 1977

Professore incaricato per il corso di "Chimica delle Sostanze Coloranti" per gli anni 1975-1981

Ricercatore confermato dal 1981 al 1992

Professore Associato dal 1992 al 2001

Professore Ordinario dal 2001 a tutt'oggi

 


Corsi di insegnamento già tenuti nell'ambito dei corsi di Laurea in CHIMICA , BIOLOGIA, BIOTECNOLOGIE, SCIENZE AMBIENTALI, OTTICA ED OPTOMETRIA, BENI CULTURALI

Chimica delle Sostanze Coloranti

Laboratorio di Chimica Organica ed Analisi Organica

Laboratorio di Chimica

Metodi Fisici in Chimica Organica

Chimica Organica Applicata all'analisi Organica

Chimica Organica

Chimica Organica dell'Ambiente

Didattica

A.A. 2015/2016

CHIMICA ORGANICA

Corso di laurea BIOTECNOLOGIE

Tipo corso di studio Laurea

Crediti 8.0

Ripartizione oraria Ore Attività frontale: 68.0 Ore Studio individuale: 132.0

Anno accademico di erogazione 2015/2016

Per immatricolati nel 2015/2016

Anno di corso 1

Struttura DIPARTIMENTO DI SCIENZE E TECNOLOGIE BIOLOGICHE ED AMBIENTALI

Percorso PERCORSO GENERICO/COMUNE

Sede Lecce - Università degli Studi

CHIMICA ORGANICA

Corso di laurea SCIENZE E TECNOLOGIE PER L'AMBIENTE

Tipo corso di studio Laurea

Crediti 6.0

Ripartizione oraria Ore Attività frontale: 62.0 Ore Studio individuale: 88.0

Anno accademico di erogazione 2015/2016

Per immatricolati nel 2014/2015

Anno di corso 2

Struttura DIPARTIMENTO DI SCIENZE E TECNOLOGIE BIOLOGICHE ED AMBIENTALI

Percorso PERCORSO COMUNE

Sede Lecce - Università degli Studi

Torna all'elenco
CHIMICA ORGANICA

Corso di laurea BIOTECNOLOGIE

Settore Scientifico Disciplinare CHIM/06

Tipo corso di studio Laurea

Crediti 8.0

Ripartizione oraria Ore Attività frontale: 68.0 Ore Studio individuale: 132.0

Per immatricolati nel 2015/2016

Anno accademico di erogazione 2015/2016

Anno di corso 1

Semestre Secondo Semestre (dal 07/03/2016 al 03/06/2016)

Lingua

Percorso PERCORSO GENERICO/COMUNE (PDS0-2010)

Sede Lecce - Università degli Studi

CHIMICA ORGANICA (CHIM/06)
CHIMICA ORGANICA

Corso di laurea SCIENZE E TECNOLOGIE PER L'AMBIENTE

Settore Scientifico Disciplinare CHIM/06

Tipo corso di studio Laurea

Crediti 6.0

Ripartizione oraria Ore Attività frontale: 62.0 Ore Studio individuale: 88.0

Per immatricolati nel 2014/2015

Anno accademico di erogazione 2015/2016

Anno di corso 2

Semestre Primo Semestre (dal 05/10/2015 al 29/01/2016)

Lingua

Percorso PERCORSO COMUNE (999)

Sede Lecce - Università degli Studi

CHIMICA ORGANICA (CHIM/06)
CHIMICA ORGANICA

Corso di laurea BIOTECNOLOGIE

Settore Scientifico Disciplinare CHIM/06

Tipo corso di studio Laurea

Crediti 8.0

Ripartizione oraria Ore Attività frontale: 68.0 Ore Studio individuale: 132.0

Per immatricolati nel 2014/2015

Anno accademico di erogazione 2014/2015

Anno di corso 1

Semestre Secondo Semestre (dal 09/03/2015 al 05/06/2015)

Lingua

Percorso PERCORSO GENERICO/COMUNE (PDS0-2010)

Sede Lecce - Università degli Studi

CHIMICA ORGANICA (CHIM/06)
CHIMICA ORGANICA

Corso di laurea SCIENZE E TECNOLOGIE PER L'AMBIENTE

Settore Scientifico Disciplinare CHIM/06

Tipo corso di studio Laurea

Crediti 6.0

Ripartizione oraria Ore Attività frontale: 62.0 Ore Studio individuale: 88.0

Per immatricolati nel 2013/2014

Anno accademico di erogazione 2014/2015

Anno di corso 2

Semestre Primo Semestre (dal 29/09/2014 al 23/01/2015)

Lingua

Percorso PERCORSO COMUNE (999)

Sede Lecce - Università degli Studi

CHIMICA ORGANICA (CHIM/06)

Pubblicazioni

ELENCO PUBBLICAZIONI 1) M.BOSCO, L.FORLANI, P.E.TODESCO and L.TROISI Unespected mobility of the Halogen in some 4-Halogenothiazoles and 5-Halogenothiazoles. J.Chem.Soc.,Chem.Comm., (1971), 1093 2) M.BOSCO, L.FORLANI, V.LITURRI, P.E.TODESCO and L.TROISI Reactìvity of the Halogeno-thiazoles toward Nucleophiles.Part III Kinetics and mechanisms of the reaction between 4(5)-X-2-Halogeno -thiazoles and Substituited Thiophenols. J.Chem.Soc.,Perkin II (1974), 508 3) M.BOSCO, L.FORLANI,P.E.TODESCO and L.TROISI Relative reactivity of groups bonded to position 2 and 5 of the Thiazole ring. J.Chem.Soc., Perkin II (1976), 398 4) M.FIORENTINO, L.TESTAFERRI, M.TIECCO and L.TROISI Metoxicarbonylation of substituted benzenes. Effect of the electronic configuration of carbon radicals in homolytic substitution. Org.Chem., (1976), 41, 173 5) M.FIORENTINO, L.TESTAFERRI, M.TIECCO and L.TROISI Displacement of the Acyl group by Alkyl Radicals. A novel SR reaction of Nitrogen contaìning Heteroaromatic compound J.Chem.Soc.,Chem.Comm., (1976), 329 6) M.FIORENTINO, L.TESTAFERRI, M.TIECCO and L.TROISI Structural effects on the reactivity of Carbon Radicals in homolytic Aromatic substitution. Part IV. The nucleophilicity of Bridgehead Radicals. J.Chem. Soc., Perkin II (1977), 87 7) M.FIORENTINO L.TESTAFERRI, M.TIECCO and L.TROISI Homolytic Aromatic ipso substitution in Benzothiazoles by the Nucleophìlic 1-Adamantil Radical. J.Chem.Soc.,Chem.Comm., (1977), 316. 8) M. FIORENTINO, L. TESTAFERRI, M. TIECCO and L. TROISI Ipso substitutìon in reaction of Acyl Radicals with 2-Substituted Benzothìazoles. J.Chem.Soc.,Chem.Comm., (1977), 317 9) M.FIORENTINO, L.TESTAFERRI, M.TIECCO and L. TROISI Displacement of the Acyl group in Benzothìazoles by Nucleophilic Alkyl Radicals. Homolytic aromatic ipso-substitution. J.Chem.Soc., (1977), 1679. 10) M.FIORENTINO, L.TESTAFERRI,, M.TIECCO, M.TINGOLI and L.TROISI Radical Alkyldenitration. A syntetically useful example of Homolytic Aromatic ipso-substitution reactìons. J.Chem.Soc.,Chem. Comm., (1978), 93. 11) L.FORLANI, P.E.TODESCO and L.TROISI Reactìvity of Halogenothiazoles towards Nucleophiles. Kinetic of reactions between 2- and 4-Halogenothiazoles and Nucleophiles. J.Chem.Soc., Perkin II, (1978), 1016 12) R.CURCI, J.O.EDWARDS, M.FIORENTINO, R.H.PATER and L.TROISI Epoxidation of Alkenes by Dioxirane intermediates generated in the reaction of Potassium Caroate with Ketones. J.Org.Chem., (1980), 45, 4758 13) R.CURCI, S.GIANNATTASIO, O.SCIACOVELLI and L.TROISI Mechanisms of peroxidic oxigen transfer to Organic Substrates. oxidation of organìc sulphides by Chromium (VI) oxide-diperoxide. Tetrahedron, (1984), 40, 2763. 14) R.CURCI, G.FUSCO, O.SCIACOVELLI, and L.TROISI 0-NMR of organic peroxides.Chromium (VI) and Molybdenum (VI) oxide diperoxide as compared to simple organic peroxides. J.Mol.Catalysis, (1985), 32, 251. 15) F.CIMINALE, R.CURCI and L.TROISI N,N-dìmethyl-p-Anisidinium cation.ESR evidence for intermolecular spin-lone pair interaction. Tetrahedron Letters, (1985), 26, 6369. 16) R.CURCI, R.MELLO and L.TROISI On the reactivity of Sililperoxides. Tetrahedron, (1986), 42, 823. 17) M.CAMPOREALE, L.CASSIDEI, R.MELLO, O.SCIACOVELLI, L.TROISI and R.CURCI On the Oxygen-17 NMR of some side-bonded dioxigen species. The Role of Oxygen in chemistry and Biochemistry, W. ANDO and Y.MORO-OKA (Eds) (1987),vol. 33, 201 18) L.CURCI, L. LOPEZ, L.TROISI, S.M.K.RASHID and P.SCHAAP Synthesis of 1,2-Dioxetanes via electron-transfer oxygenation. Tetrahedron Letters, (1987), 28, 5319. 19) F.CIMINALE, R.CURCI, M.PORTACCI and L.TROISI On the e.s.r. Identification of paramagnetic species observed during set oxidation of N,N-dimethyl-p-Anisidina. Tetrahedron Letters, (1988), 29, 2463. 20) R.CURCI, L.LOPEZ, L.TROISI, S.M.K.R.ASHID, and A.P.SCHAAP Oxidation of enol ethers by Metal(VI)oxide diperoxide. Tetrahedron Letters, (1988), 29, 3145. 21) F.CIMINALE, M.CAMPOREALE, R.MELLO, L.TROISI and R.CURCI Oxidation of Tertiary Amínes by Chromium(VI)oxide diperoxìde. J.Chem.Soc. Perkin II, (1989), 417. 22) L.TROISI, L.CASSIDEI, L.LOPEZ, R.MELLO and R.CURCI Oxidation by methyl-trifluoromethyl dioxirane. Epoxidation of Enol ethers. Tetrahedron Letters, (1989), 30, 257. 23) L.LOPEZ, V.CALO¿ and L.TROISI Selective Allylic Electron-transfer ossidation of b-ionone J.Chem.Soc. Chem. Comm., (1989), 25. p 24) L.LOPEZ, L.TROISI, S.M.K.RASHID and A.P. SCHAAP Synthesis of 1,2-Dioxetanes via 9,10-Dicianoanthracene-sensitized chain electron-transfer Photooxygenations Tetrahedron Letters, (1989), 30, 485. 25) L.LOPEZ and L.TROISI Electron-transfer ìnduced conversion of Enol-ethers into Ketones. Tetrahedron Letters, (1989), 30, 489. 26) L.LOPEZ and L.TROISI Electron-transfer chain Isomerizatìon of Epoxides induced by one-electron oxidizing agents. Tetrahedron Letters, (1989),30, 3097. 27) M.CAMPOREALE, T.FIORANI, L.TROISI, W.ADAM, R.CURCI and J.O.EDWARDS On the Mechanism of the Baeyer-Villiger oxidation of Ketones by Bis(trimethylsilyl) peroxomonosulfate. Intermediacy of Dioxiranes. J.Org.Chem., (1990), 55, 93 28) S.FLORIO and L.TROISI Reaction of Bistrimethylsilylperoxide with 2-Benzothiazolylalkyllitiums: an unprecedented demethylation. Tetrahedron Letters, 1989 , 30, 3721 29) E.EPIFANI, S.FLORIO and L.TROISI Alkylation of Heteroaryl Alkyl Metals by Bistrialkylsilylperoxides. Tetrahedron, (1990), 46, 4031 30) L.LOPEZ, L.TROISI and G.MELE Electron-transfer reactions on Hindered olefins induced by Aminium Salts. Tetrahedron Letters, (1991), 32, 117 31) E.EPIFANI, S.FLORIO, G.INGROSSO, L.RONZINI, R.SGARRA, L.TROISI Regio- and Strereo-chemístry of The Coupling Reaction of Phenylsulphenyl-, Phenylsulphinyl- and Phenyl-sulphonyl Metals. Tetrahedron, (1991), 35, 7489 32) L.LOPEZ, L.TROISI Electro-transfer Reactíons on Enol-Ethers Induced by Aminium Salts. Synthesis of 1,2-Dioxetanes and/or Ketones. Terahedron, (1992), 35, 7321 33) L.LOPEZ, L.TROISI 9,10-Dicyanoanthracene sensitized chain Photooxygenatíon of alkoxy(aryl)methylidene- adamantanes. Gazz. Chim. It., 122, (1992) 34) S.FLORIO, L.TROISI 2-Benzothiazolylchloromethyllitium: Synthesis of Oxiranes. Tetrahedron Letters, (1992), 51, 7953 35) S.FLORIO, G.INGROSSO, L.TROISI, L.LUCCHINI Lithiation of Benzothìazolyl Substituted epoxides and Reaction with Electrophiles Tetrahedron Letters, (1993), 34, 136.3 36) S.FLORIO, L.TROISI On the Reaction of Silylperoxides with Carbanions Tetrahedron Letters, (1993), 34, 3141 37) S.FLORIO, L.TROISI Líthiation of 2-ChloromethylPyridin: Synthesís of 2- Oxiranylpyridine. Tetrahedron Letters, (1994), 35, 3175 38) L.LOPEZ, G.MELE, A.NACCI., L.TROISI One-Pot conversion of a-Substituted Arylacetaldehydes into a-Dícarbonyl compounds, Tetrahedron Letters, (1993), 34, 3897. 39) S.FLORIO, V.CAPRIATI, MC.SOLIMINI, L.TROISI Self-condensation of Benzothiazolylchloromethyllitium Tetrahedron Letters, (1994), 35, 8481-84. 40) S.FLORIO, L.TROISI, V. CAPRIATI Heteroarylchloromethyllitiums as Darzens Reagents: Synthesís of Heteroaryl Aziridines. J.Org.Chem, (1995), 60, 2279-2282 41) S.FLORIO, L.TROISI, V.CAPRIATI Ring expansion of 2-Chlorometylbenzothíazole: Synthesis of Heteroarylalkylídene 1,4-Benzothiazine. Tetrahedron Letters, (1995) 36,1913-16 42) S.FLORIO, L.TROISI Generatíon and Synthetic Applications of (3-Pyridinylchloromethyl)litium. J.Org.Chem., (1996) 61, 4148-4150 43) S.FLORIO, L.TROISI Lithiation of Allylchlorides and Reactions with Electrophiles. Tetrahedron Letters, (1996) 37, 4777-80. 44) S.FLORIO, L.TROISI, V.CAPRIATI Synthesis of 2-Oxiranyl and Aziridinl Thiazoles. Tetrahedron Letters, (1998) 39, 7951-7954. 45) L.TROISI, S.FLORIO, G.MELE, G.VASAPOLLO, V.CAPRIATI, B. EL ALI Palladium(II) Catalized Regioselective Lactonization of steroids. Chemoselective construction of novel estrone derivatives. Tetrahedron Letters, (1999) 40, 1777. 46) S.FLORIO, L.TROISI, V. CAPRIATI, G.COLETTA Heterosubstituted Chlorohidrins: Knoevenagel Reaction versus Epoxide Formation Tetrahedron, (1999) 55, 9859. 47) S.FLORIO, L.TROISI, V.CAPRIATI, G.INGROSSO Synthesis of Oxazolinyl Aziridines Tetrahedron Letters, (1999) 40, 6101. 48) S.FLORIO, L.TROISI, V. CAPRIATI, G.SUPPA Lithiation of Cinnamyl Chloride: Stereoselective Synthesis of Propargylic Oxiranes and Aziridines Eur. J.Org. Chem., (2000) 22, 3793-3797. 49) L.PASIMENI, M. MENEGHETTI, R. RELLA, L. VALLI, C. GRANITO, L. TROISI Preparation and spectroscopic characterization of Cu(II)-[tetrakis(3,3dimethyl-l-butoxycarbonyl)] phthalocyanine thin films deposited by the Langmuir-Blodgett technique. Thin Solid Films, 265, (1995) 58-65 50) L. PASIMENI, R. RELLA, L. TROISI, L. VALLI Spectroscopic characterization of a substituted phthalocyanine thin film deposited by the Langmuir-Blodgett technique. Materials Science Forum, 203, (1996) 297-302 51) D. MANNO, R. RELLA, L. TROISI, L. VALLI Langmuir-Blodgett films of Cu(II)-tetrakis(3,3-dimethyl-l-butoxycarbonyi) phthalocyanine: a spectrophotometric and TEM analysis of their structure and morphology. Thin SolidFilms, 280, (1996) 249-255. 52) R. RELLA, L. VALLI, A. SERRA, L. TROISI, P. SICILIANO, A. TEPORE, Characterization of a novel phthalocyanine Langmuir-Blodgett film for N02 detection. Thin SolidFilms, 285, (1996) 870-872. 53) D. MANNO, R. RELLA, A. SERRA, P. SICILIANO, A.TAURINO, L. TROISI, L.VALLI. Langmuir-Blodgett films of a phthalocyanine simmetrically functionalized with eight ester units. Materials Science and Engineering, C5 (1998) 317-320 54) S.CAPONE, R.RELLA, P.SICILIANO, L.VASANELLI, L.VALLI, L.TROISI On the characterization and gas sensing properties of Cu(II) tetra(alkylaminocarbonyl)phtalocyanine LB films. Thin Solid Films, 327-329, (1998) 465-468. 55) L.PASIMENI, M. RUZZI, L. FRANCO, L. TROISI V. RIZZO, M. PRATO Improved charge separation in porphyrin-difullerene triads J. Chem. Soc. Chem. Comm., (0000) 56) L.PASIMENI, M. RUZZI, L. FRANCO, L. TROISI V. RIZZO, M. PRATO Triads and tetrads of porpfyrin with fullerene linked by covalent and coordination bond. Long-lived charge-separate states detected by time resolved electron paramagnetic resonance. Phis.Chem. Chem. Phis., (0000) 57) V. CAPRIATI, L. DE GENNARO, S. FLORIO, R. LUISI, C. TRALLI, L. TROISI Lithiation of 2-(1-Chloroethyl)-2-Oxazolines; Synthesis of Substituted Oxazolinyloxiranes and Oxazolinylaziridines; Synthesis (2001), 15, 2299-2306. 58) L. TROISI, S. FLORIO, G. INGROSSO, C. GRANITO, V. CAPRIATI [1,2] and [2,3] Wittig Stereoselective and Competitive Rearrangement of Heteroarylallyl ethers; Eur, J. Org. Chem. (2002), 478-484. 59) L. TROISI, S. FLORIO, C. GRANITO Chemosective construction of novel steroids derivatives; Steroids (2002), 67, 687-693 60) D.M. GULDI, F. PELLARINI, M. PRATO, C.GRANITO, L. TROISI Layer-by-Layer Construction of Nanostructures Porphyrin-Fullerene Electrodes; Nanoletters (2002), 2, 965-968. 61). S. FLORIO, G. INGROSSO, C. GRANITO, L. L.TROISI Wittig Rarrangement of (Heteroaryl)alkyl Propargyl Ethers ¿ Synthesis of Allenic and Propargylic Alchols; Eur, J. Org. Chem. (2002), 3465-3472. 62) F. BONA, L. DE VITIS, S. FLORIO, L. RONZINI, L. TROISI Diastereoselective synthesis of 2-oxiranyl and 2-aziridinyl thiazoles; Tetrahedron (2003), 59, 1381-1387. 63) S. FLORIO, C. GRANITO, G. INGROSSO, L. TROISI Regio- and stereo-selective coupling reactions of heteroarylalkyl propargyl ethers with electrophiles; Arkivoc (2002), 216-226 64) S. FLORIO, P. LORUSSO, C. GRANITO, L.RONZINI and L. TROISI Vicarious Nucleophilic Substitution of (Chloroalkyl)oxazolines with Nitroarenes: Synthesis of (Nitrobenzyl)oxazolines. Eur, J. Org. Chem. (2003), 4053-4058 65) L. DE VITIS, S. FLORIO, C. GRANITO, L. RONZINI, L TROISI, V. CAPRIATI, R. LUISI, and T. PILATI Stereoselective Synthesis of Heterosubstituted Aziridines and their Functionalization; Tetrahedron (2004), 60, 1175-1182 66) L. TROISI, L. DE VITIS, C. GRANITO and E. EPIFANI. The Stereoselective Synthesis of Alkenyl- b- lactams by Palladium-Catalyzed [2+2] Carbonilative Cycloaddition. Eur, J. Org. Chem. (2004), 1357-1362. 67) S. FLORIO, P. LORUSSO, R. LUISI, C. GRANITO, L.RONZINI, AND L.TROISI Vicarious Nucleophilic Substitution of (Chloroalkyl)heterocycles with Nitroarenes. Eur, J. Org. Chem. (2004), 2118-2124. 68) C. GRANITO, L. TROISI, AND L. RONZINI Palladium-catalyzed Cyclocarbonylation of Unsaturated Alcohols and Amines. Chemoselective Synthesis of Heterocycle-substituted g- and d-lactones and lactams Heterocycles, (2004), 63, 1027-1044. 69) L. TROISI, L. DE VITIS, C.GRANITO, T. PILATI, E. PINDINELLI [2+2 ] Carbonylative cycloaddition catalyzed by palladium: stereoselective synthesis of b-lactams. Tetrahedron (2004), 60 (32) 6895 6900 70) S. FLORIO, P. LORUSSO, C. GRANITO, R. LUISI, and L. TROISI One-Pot Regioselective Synthesis of Nitrophenyloxazolinyl Stirene Oxides by the Darzens Reaction of Vicarious Nucleophilic Substitution- Formed Carbanion of 2-Dichloromethyl-4,4-dimethyloxazoline. J.Org.Chem (2004), 69, 4961-4965 71) L. TROISI, L. DE VITIS, C. GRANITO, P. METRANGOLO, T. PILATI and L. RONZINI Diastereo- and enantioselective syntheses of heteroaryloxiranes ; Arkivoc (2004) (xiv) 61-73 72) L.TROISI, C. GRANITO and E. PINDINELLI Properties, Synthesis and Functionalizations of b-lactams. Target in heterocyclic systems vol 8 (2004) 187-215. 73) L. TROISI, E. PINDINELLI, L. DE VITIS, C. GRANITO and L. RONZINI Stereoselective Functionalization of Alkenyl-b-Lactams. Heterocycles, (2005), 65, 2871-2884. 74) L. TROISI, C. GRANITO, C. CARLUCCI, F. BONA, S. FLORIO Synthesis and Functionalization of 2,3-Diheterosubstituted-aziridines. Eur, J. Org. Chem (2006) 775-781. 75) L. TROISI, L. RONZINI, C. GRANITO, L. DE VITIS, and E. PINDINELLI Stereoselective Synthesis and Functionalization of 4-Heterosubstituted b-lactams. Tetrahedron (2006), 62, 1564-1574 76) S. FLORIO, M. MAKOSZA, P. LORUSSO, L. TROISI Oxidative Nucleophilic Substitution of Hydrogen in Nitroarenes with Oxazoline Stabilised Carbanion Arkivoc (2006), (vi), 59-66. 77) L.TROISI, C. GRANITO, E. PINDINELLI, L. DE VITIS Cyclocarbonylation of Unsatured Amines. Chemo and Stereoselective Synthesis of N-Heterosubstituted g and d-Lactames via Palladium-catalyzed. Arkivoc (2006), (vi), 161-173 78) L. TROISI, L. RONZINI, C.GRANITO, E. PINDINELLI, A.TROISI, T. PILATI Synthesis and isomerization of N-a-aza-heteroaryl-b-lactams. Tetrahedron 62 (2006), 12064-12070 79) L. DE VITIS, L. TROISI, , C.GRANITO, E. PINDINELLI, L. RONZINI Tandem-Selective Bond Cleavage of the b-Lactam Nucleus and Michael Reaction. Eur, J. Org. Chem (2007) 356-362. 80) L. TROISI, C. GRANITO, E. PINDINELLI, L. RONZINI Stereoselective Synthesis of Polyfunctionalized Aziridines. Heterocycles 71 (2007) 1381-1396 81) E. PINDINELLI, T.PILATI, L. TROISI Synthesis and rearrangement of 1,2,3-Triheteroaryl(aryl)-substituted Aziridines. Eur, J. Org. Chem (2007) 5926-5933 82) M.FABIO, L. RONZINI, L.TROISI Synthesis of new 3,5-diarylisoxazolidines by cycloaddition of oxaziridines and alkenes. Tetrahedron 63 (2007), 12896-12902 83) M.FABIO, L. RONZINI, L.TROISI Synthesis of stable isoxazolines by [3+2] cycloaddition of oxaziridines with alkynes. Tetrahedron 64 (2008), 4979-4984 84) L. TROISI, S. DE LORENZIS, M. FABIO, F. ROSATO, C. GRANITO Chiral oxaziridines in the enantioselective synthesis of isoxazolidines. Tetrahedron: Asymmetry 19 (2008) 2246-2251. 85) L. TROISI, C. GRANITO, E. PINDINELLI Stereoselective synthesis and functionalization of N-alkyl-b-lactams Tetrahedron 64 (2008), 11632-11640 86) L. TROISI, E. PINDINELLI, V. STRUSI, P. TRINCHERA Stereoselective synthesis of 3,4-diaryl-beta-lactams. Tetrahedron: Asymmetry 20 (2009) 368-374 87) L.TROISI, L. RONZINI, F. ROSATO, V. VIDETTA [3+2] Cycloaddition of Oxaziridines with Nitriles: Synthesis of 2,3-Dihydro-1,2,4-Oxadiazoles Synlett 11, (2009) 1806-1808. 88) L.TROISI, C. GRANITO, F. ROSATO, V. VIDETTA Arkivoc (2009), (xiv) 324-336.  89) L.TROISI, C. GRANITO, F. ROSATO,  V.VIDETTA; One-pot amide synthesis from allyl or benzyl halides and amines by Pd-catalysed carbonylation,  Tetrahedron Lett. 51, (2010), 371.373. 90)G. CANNAZZA, M.M. CARROZZO, U. BATTISTI, D. BRAGHIROLI, C.PARENTI. L.TROISI, A.TROISI. Determination of Kinetic Parameters of Enantiomerization of Benzothiadiazines by DCXplorer, Chirality 22. (2010) 289-297. 91) L.TROISI, S. CACCAMESE, T. PILATI, V. VIDETTA, F.ROSATO; [3+2] Cycloaddition reaction between chiral oxaziridines and nitriles: enantioselective synthesis of 2,3-dihydro-1,2,4-oxadiazoles. Synthesis (2010) 18, 3211-3216. 92)U. BATTISTIG. CANNAZZA, M.M. CARROZZO, , D. BRAGHIROLI, C.PARENTI.F.ROSATO,  L.TROISI; Regioselective reduction of 3-substituted 2,3-dihydrobenzothiazines with borohydrides. Tetrahedron Lett. 51 (2010) 4433-4436. 93) L.TROISI, C.GRANITO, E. PINDINELLI, Novel and Recent Synthesis and Application of Beta-Lactams. Top Heterocycl. Chem. (2010) 22: 101-209 DOI 10.1007/7081_2009_12. 94) L.TROISI,C. GRANITO, L. RONZINI, F. ROSATO, V. VIDETTA; An Economic and Efficient Tetrahydrofuranylation of Alcohols, Imines and Alkynes.Tetrahedron Lett. 51 (2010) 5980-5983. 95) V.VIDETTA, S. PERRONE, F. ROSATO, P. ALIFANO, S.A.TREDICI, L. TROISI; Condensed Oxaziridine-Mediated [3+2] Cycloaddition: Synthesis of Polyhetero-bicyclo Compounds.  Synlett (2010) 18, 2781-2783. 96) S. PERRONE, T. PILATI, F. ROSATO, A. SALOMONE, V. VIDETTA, L. TROISI; Azodioxy-carbonyl compounds by oxidation of cyclic imines with m-CPBA. Terahedron 67, (2011) 2090-2095. 97)M.M. CARROZZO, G. CANNAZZA, U. BATTISTI  , D. BRAGHIROLI, C.PARENTI.  L.TROISI; Epimerization and hydrolysis of 3,6-dimethyl-2,3,5,6-terahydro[1,2,4]thiadiazino[6,5,4-hi]indole-1,1-dioxide. J. Chromatography A  1217 (2010) 8136-8145.

98) L.TROISI,  C. GRANITO, S. PERRONE, F. ROSATO

Synthesis of Benzofused Five and Six-membered Heterocycles by Palladium-Catalyzed Cyclocarbonilation. Tetrahedron. Letters. 52,( 2011) 4330-4332.

 

 

99) S. PERRONE, F. BONA, L. TROISI

Palladium-catalized Acylation and/or Homo-coupling of Aryl and Alkyl-acetylenes

Tetrahedron (2011) 67, 7386-7391

 

100) L.TROISI, F. ROSATO

2-tert-Butyl-3-phenyl-oxaziridine. Encyclopedia of Reagents for Organic Synthesis  (review )e-EROS  J.Wiley & Sons Ltd editor  (15.09.2011) ISBN 9780470842898

DOI: 10.1002/047084289X.rn01335.

 

101)Brevetto

 

102) B. M. Battisti, K. Jozwiak , G. Cannazza, G.Puia, G. Stocca , D. Braghiroli, C. Parenti, L. Brasili , M. M. Carrozzo, C. Citti, L . Troisi.

 5-Arylbenzothiadiazine type compounds as positive allosteric modulators of AMPA/Kainate receptors ACS Medicinal Chemistry Letters (2012)  3, 25-29

103) U.M. BATTISTI, M.M. CARROZZO, G. CANNAZZA, G. PUIA, L. TROISI, D. BRAGHIROLI, C. PARENTI, K. JOZWIAK

Molecular modeling studies, synthesis, configurational stability and biological activity of 8-chloro-2,3,5,6-tetrahydro-3,6-dimethyl-pyrrolo[1,2,3-de]-1,2,4-benzothiadiazine 1,1-dioxide. ACS Biorganic & Medicinal Chemistry  v.19 issue 23 (2011)  7111-7119.

 

 

104) U. M. BATTISTI, M. M. CARROZZO, G. CANNAZZA, D. BRAGHIROLI, C. PARENTI, L. BRASILI, C. CITTI, L. TROISI

Efficient synthesis of 5,6-dihydro-8H-[1,2,4]thiadiazino[6,5,4-de]phenanthridine 4,4-dioxide and 5,6-dihydro-8H-[1,2,4]-thiadiazino[6,5,4-ij]thieno[2,3-c]quinoline 4,4-dioxide Tetrahedron Letters  (2012) 53 (9), 1122-1129

 

 

105) S. TOMMASI, S. PERRONE, F. ROSATO, A. SALOMONE, AND L. TROISI*

One-pot ester synthesis from allyl or benzyl halides and alcohols by Pd catalyzed

Carbonylation.  Synthesis  (2012) , 44, 423-430.

 

 

 

106)     M. M. CARROZZO; U. M.BATTISTI: G. CANNAZZA; C.CITTI; C. PARENTI; L. TROISI 

Regioselective cyclization of chloroacylaminobenzensulfonamide derivative; Tetrahedron Letters  53 (2012) 3023-3026


 

Temi di ricerca

1) Messa a punto di nuove metodologie sintetiche per prodotti eterociclici di chiaro interesse Biologico , Farmaceutico e nuovi  Materiali per celle solari

Ossaziridine, aziridine, beta-lattami, gamma delta e epsilon lattoni e lattami, ossazoline, ossazolidine, ossadiazoline ossadiazolidine, ossirani e numerosi altri eterocicli sono stati ottenuti con nuove metodologie sintetiche messe a punto nel Laboratorio di Chimica Organica di Lecce di cui sono responsabile.

Le oxaziridine condenzate ad altri cicli ( ottenute a partire da Amminoacidi naturali e di sintesi) si sono rilevate ottimi precursori per la sintesi di C-Nitroso composti, il cui utilizzo nel campo farmacologico potrebbe essere quello di fornitore di ossido nitrico. ( vedi utilizzo di arginina per lo stesso scopo)

 i beta-lattami da noi preparati hanno mostrato una chiara attività batteriologica, con test fatti in vitro e in vivo,

le aziridine e vari tipi di lattoni e lattami presentano una potenziale attività per la cura di malattie delle piante. La Bayer-  crop-science chiede spesso questo tipo di substrati per i loro test.

Sono stati sintetizzati inoltre farmaci di elevata potenziale applicabilità per la cura di malattie mnemodegenerative ( 1,2,3-benzotiadiazinici-1,1diossido) modulatori allosterici del ricettore AMPA, con relativo brevetto.

2) Estrazione di principi attivi da piante: Oleuropeina dalle foglie d'ulivo, Artemisina dall'artemisia, Antocianine da piante e frutti, Flavonoidi e fenoli vari dall'Azadiracta-indica

3) Sintesi di Porfirine e derivati Porfirine-Ffullerene per la formazione di sensori.