Progetti di Ateneo

angle-left An integrated approach to tackle the interplay among adaptation, stressful conditions and antimicrobial resistance of challenging pathogens
Codice Progetto o altro Identificativo
Denominazione Progetto
Progetto PRIN 2017 – Cod. 2017SFBFER
Tipologia di finanziamento
Tipologia ambito della fonte di finanziamento
Fonte di finanziamento
Fondi PRIN 2017
Sottoprogramma/ASSE /Misura/Azione/Linea di finanziamento
Settore LS6 – Linea C
Call e/o Bando specifici
Bando Prin 2017 - Decreto Direttoriale n. 3728 del 27 dicembre 2017
Referente Scientifico (nome e cognome)
Pietro Alifano
Compagine Progettuale
Università degli Studi di Catania; Università degli Studi di Napoli “Federico II”; Università degli Studi “G. d’Annunzio” Chieti-Pescara; Università degli Studi di Sassari; Università del Salento; Consiglio Nazionale delle Ricerche – Istituto di Biostrutture e Bioimmagini
Data inizio
Data fine
Rapidly emerging resistant bacteria threaten the extraordinary health benefits that have been achieved with antibiotics. This crisis is global, reflecting the worldwide overuse of these drugs and the lack of development of new antibiotic agents. Antibiotic-resistant infections place a substantial health and economic burden on the Italian health care system. Understanding the scientific basis of antimicrobial resistance is essential in combatting this public health threat and should cover the knowledge of resistance mechanisms, new knowledge on the genome and resistome structure of resistant bacteria, but also the adaptive phenomena that can emerge as a consequence of antibiotic concentration gradients and other stresses occurring in human patients. This research proposal, organized in 3 WPs, gathers together 6 research units (RUs), with the final goal of acquiring new information on: i) genome and resistome; ii) mechanisms of action and resistance; and iii) adaptive mechanisms under stress conditions, in different challenging pathogens. Expected outputs: genome and resistome insights; mechanism of resistance influenced by stress and slow growing conditions; involvement of stringent response as a possible target for disarming pathogens.
Ambito tecnologico produttivo
Biotecnologie per la salute dell’uomo